Most physicians, however, will administer N-acetyl cysteine even if the patient is first seen beyond this 16-hour period. All enzyme elevations returned to normal after stopping Tylenol. Beyond that, two adults should independently determine the dose of acetaminophen for a child. Ibuprofen, aspirin and acetaminophen toxicosis and treatment in dogs and cats., Crippin, J. S. (1993). If the person suspected to have taken an overdose of acetaminophen is unconscious, semiconscious, or not breathing, call 911 immediately. In children, a single dose of 140 mg/kg (body weight) of acetaminophen can result in liver injury. La FDA agencia para medicamentos y alimentos de los EE. A physician should evaluate the individual immediately. It seems that certain individuals like those who regularly drink alcohol, are more prone than others to developing acetaminophen-induced liver damage. Treatment for This type of Tylenol contains 650 mg acetaminophen per caplet, has the same bi-layer design, and is formulated to relieve minor muscle aches and body pain fast and to last all day. Los nios tienen una menor capacidad de glucuronidacin, lo que los hace ms susceptibles a sufrir este trastorno. Otros indicadores de un mal pronstico mdico incluyen insuficiencia renal, grado 3 o mayor de encefalopata heptica, un tiempo de protrombina marcadamente elevado o un aumento en el mismo del da 3 al 4. How does an overdose of acetaminophen cause liver injury? Scottish Intercollegiate Guidelines Network, (SIGN) (2008). En los Estados Unidos y Canad se vende como Tylenol 1/2/3/4. This is so regardless of the cause of the liver disease and provided the patient does not drink alcohol regularly. Tylenol 8-Hour Aches and Pains ER . An antidote, N-acetyl cysteine, is available and should be given to the patient as soon as possible, preferably within 16 hours after the acetaminophen was taken. See a picture of the Liver and learn more about the health topic. Skip the missed dose if it is almost time for your next scheduled dose. The techniques used to perform liver biopsy include percutaneous liver biopsy, transvenous liver biopsy, and laparoscopic liver biopsy. 40 Aluminum Lake, Polyethylene Glycol, Titanium Dioxide, FD&C Yellow no. Note that this amount is about twice the recommended maximum dose for a 24-hour period. This is usually pain from colds, sore throats, headaches, body or muscle aches, menstrual cramps, arthritis, or toothaches. Go to the hospital's emergency department if the. Acetaminophen hepatotoxicity: potentiation by isoniazid., Nolan, C. M., Sandblom, R. E., Thummel, K. E., Slattery, J. T., Nelson, S. D. (1994). Otros estudios han mostrado que el carbn activado parece ser beneficioso para el paciente. Debido a la amplia disponibilidad sin receta del paracetamol (acetaminofn) como Especialidad Farmacutica Publicitaria, EFP=OTC (OTC en los EE. Sibling rivalry is normal but is it helpful or harmful? In rare cases, people have had allergic reactions to it. Most people don't experience side effects with this drug when it is used appropriately. All rights reserved. BONUS! What Procedures and Tests Diagnose Acetaminophen (Tylenol) Poisoning? Taking too much acetaminophen can cause liver damage. The doctor inserts the biopsy needle, covered in a thin, flexible sheath, through the jugular vein in the neck down into the livers primary vein (hepatic vein) to access the liver. (Some other medications can cause liver injury in an unpredictable fashion that is unrelated to the dose.) Estudios recientes indican que el paracetamol podra aparentemente modular el sistema cannabinoide endgeno en el cerebro a travs de su metabolito, AM404 (N-arachidonoylaminophenol), que parece inhibir la recaptacin de la anandamida endgena por lo que est ms disponible para reducir el dolor, as como posiblemente activar directamente el TRPV1 que tambin inhibe las seales de dolor en el cerebro. 2022 WebMD, Inc. All rights reserved. 10 Things People With Depression Wish You Knew. De esta forma, mientras el AAS acta como un inhibidor irreversible de la COX y bloquea el centro activo de la enzima directamente, el paracetamol la bloquea indirectamente y este bloqueo es intil en presencia de perxidos. An overdose of acetaminophen can damage your liver or cause death. Este absorbe bien el paracetamol, y por lo tanto se reduce la cantidad que se absorbe en el tracto gastrointestinal. Brok, J., Buckley, N., Gluud, C. (22 de febrero de 2006). Use your childs weight to decide on the right amount to give. Craen, Anton J. M. de; Giulio, Giuseppe Di; Lampe-Schoenmaeckers, Angela J. E. M.; Kessels, Alphons G. H.; Kleijnen, Jos (1996). However, if you use too much, the side effects can be severe and even deadly. In other words, liver injury from acetaminophen occurs only when someone takes more than a certain amount of the drug. Tylenol (acetaminophen) is only effective at relieving pain and fever, but Advil (ibuprofen) relieves inflammation in addition to pain and fever. El uso en combinacin con otros medicamentos que inducen la sntesis de enzimas CYP, como los antiepilpticos (carbamazepina, fenitona, barbitricos, etc.) Tylenol 8-Hour Aches and Pains Extended-Release is basically the same as the formulation for arthritis pain. El paracetamol se utiliza para reducir la fiebre en personas de todas las edades,[18] sin embargo la Organizacin Mundial de la Salud (OMS) recomienda que solo se utilice paracetamol en nios cuando su temperatura corporal sea superior a 38,5C. Get emergency medical help if you have signs of an allergic reaction to Tylenol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Harmless at low doses, acetaminophen has direct hepatotoxic potential when taken as an overdose and can cause acute liver injury and death from acute liver failure. 40 Aluminum Lake, Polyethylene Glycol, Titanium Dioxide, FD&C Yellow no. To make this determination, they obtain the patient's history of acetaminophen ingestion and measure the blood level of the drug. For the average healthy adult, the recommended maximum dose of acetaminophen over a 24-hour period is four grams (4000 mg) or eight extra-strength pills. El dao se da generalmente en los hepatocitos a medida que van metabolizando el paracetamol. La quinina en s misma tambin tiene actividad antipirtica. We'll tell you how these decongestants are alike and different. Less serious Tylenol side effects may be more likely, and you may have none at all. But it need not happen to you. Although they dont occur in most people, some effects can be serious. An initial step in detecting liver damage is a simple blood test to determine the presence of certain liver enzymes in the blood. antibiotics, antidepressants, anti-cancer agents, and drugs used in controlling Como se mencion anteriormente, el paracetamol es metabolizado en compuestos inactivos por combinacin con sulfato y cido glucurnico, siendo una pequea parte metabolizada por el sistema del citocromo P-450. Ibuprofen vs. Acetaminophen: How Are They Different? Use exactly as directed on the label. FDA OKs Bivalent COVID Boosters for Kids 6 Months and Older, Twins Study Shows Exercise Altering How Genes Behave, Vitamin D Might Help Shield the Aging Brain, AHA News: You're Not a Polar Bear: The Plunge Into Cold Water Comes With Risks. Adems, la COX tambin participa en la sntesis de tromboxanos que favorecen la coagulacin de la sangre; el AAS tiene efectos antiagregantes, pero el paracetamol no. Tylenol Regular Strength Liquid Gels temporarily reduce fever and relieve minor aches and pains. Drug-induced liver disease. La biodisponibilidad es muy elevada (cercana al 100%), siendo la biodisponibilidad por va oral del 75-85%. Tylenol is the brand name for the drug acetaminophen, and it works by disrupting pain signals in the body. La NAC es eficaz si se administra con prontitud, pero puede ser efectivo aun cuando hayan transcurrido 48 horas de la sobredosis. Secondary headaches are caused by disease. Childrens TYLENOL Chewables reduces fevers and relieves pain in children ages 2-11 years, Childrens TYLENOL comes from the pain relief brand recommended most by pediatricians. Your individual acetaminophen limit may also be affected by your age or certain lifestyle habits. Overeating? The liver is a large, meaty organ that sits on the right side of the belly. Cuando la quina empez a escasear en los aos 1880, la gente empez a buscar alternativas. It's available over-the-counter as brand names such as Tylenol, Mapap or Panadol, and also as generics and store-specific brands. En condiciones normales, la NAPQI se neutraliza por accin del glutatin. pain with However, if you take acetaminophen at the recommended dosage, liver damage from the drug is not likely. Read and carefully follow any Instructions for Use provided with your medicine. Even though Tylenol most likely does not cause serious liver damage in recommended doses, it can cause elevations of liver enzymes in the blood suggesting injury to the liver. La hepatotoxicidad del paracetamol se puede diagnosticar si despus de una sobredosis de paracetamol el AST y ALT superan los 1000UI/L. Este preparado se ha usado con xito durante aos en otros pases, como Australia, Canad y Gran Bretaa. Thanks for visiting. obliga a fabricantes a informar que el paracetamol, cuando se administra en dosis muy altas o junto con bebidas alcohlicas, puede ser altamente txico y potencialmente mortal, en virtud de los daos que puede causar al hgado. Overall it is important that anyone suspected to have taken an overdose of acetaminophen get treatment early, before symptoms occur. What Are the Best PsA Treatments for You? Los anlisis deben repetirse, al menos, diariamente. If so, then youve taken acetaminophen. An excessive amount of acetaminophen in the liver, however, can overwhelm (saturate) the sulphation and glucuronidation pathways. En general, en la hepatotoxicidad inducida por paracetamol, los niveles de AST son algo superiores a los de ALT. Abdominal pain can have many causes that range from mild to severe. Seek emergency medical care at a hospital's emergency department in these situations. Tylenol is a very effective pain-killing (analgesic) and fever-reducing (anti-pyretic) agent. WebAcetaminophen (Tylenol) is a pain medicine. NSAIDs can make you sick, too, but it takes a larger amount to reach a dangerous overdose. Dicho tratamiento consiste en una administracin inicial de 150mg/kg durante 15 minutos, seguido de 50mg/kg durante las cuatro horas siguientes y finalmente 100mg/kg durante las 16 horas restantes. But in some people, doses close to the 4,000 mg daily limit for adults could still be toxic to the liver. For the remainder of this discussion, we will refer to the generic name acetaminophen, rather than to the brand name Tylenol. Over many years, it has been used countless times by many people and it has proven to be a safe and effective medication. When a person is given a new medication, always make sure the doctor knows all of the medication and. [24] El paracetamol tiene relativamente poca actividad antiinflamatoria, a diferencia de otros medicamentos muy utilizados como la aspirina o el ibuprofeno, que forman parte de los AINE, aunque el ibuprofeno y el paracetamol tienen efectos similares en el tratamiento del dolor de cabeza. Las concentraciones son similares en la sangre, la saliva y el plasma. Hay discrepancias en cuanto a cambiar la dosis de N-acetilcistena administrada, o incluso si esta debe modificarse. Purpose Pain reliever/fever reducer. Acetaminophen controls pain and fever but does not reduce inflammation, as doesaspirinand the other widely consumed nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen (Advil, Motrin, generics) and naproxen (Aleve, generics). 6 Aluminum Lake, Polysorbate Esta pgina se edit por ltima vez el 10 dic 2022 a las 22:04. La corteza de la quina era usada para la obtencin de quinina, compuesto con actividad antimalaria. Similarly, each tablet of hydrocodone/acetaminophen (Vicodin), a popular, potent painkiller that contains a narcotic, has also 500, 650, or 750 mg of acetaminophen, depending on the formulation. Serious side effects of Acetaminophen. Hepatitis: Surprising Things That Can Damage Your Liver. Tobias, Jeffrey S.; Hochhauser, Daniel (2014). They do this by making the cytochrome P-450 system in the liver more active. Use these dosage charts for infants and children under 12 years old: aspirin, acetaminophen, ibuprofen, tramadol, cyclobenzaprine, Paracetamol, diclofenac, naproxen, oxycodone, Voltaren. Understand that acetaminophen does not target inflammation, so if your arthritis pain comes with swelling, acetaminophen may not serve your needs completely. Este hecho se produjo en 1873, pero el paracetamol no se us con fines mdicos durante dos dcadas. Its not fully known how acetaminophen works. En algunas formulaciones el paracetamol se combina con el opioide codena, a veces llamado co-codamol, como por ejemplo el Algidol (Almirall) en Espaa, lo que lo convierte en ms txico[citarequerida]. Davies, Reece A.; Maher, Christopher G.; Hancock, Mark J. Sus efectos duran entre dos y cuatro horas. Existen nomogramas de paracetamol que permiten estimar el riesgo de toxicidad basndose en su concentracin en suero sanguneo tras un determinado nmero de horas. (2014, August 15). Age of child: Do not use acetaminophen under 12 weeks of age unless your pediatrician tells you to. Michael J Ameres, MD, The antidote to acetaminophen overdose is N-. For therapy options beyond the standard approaches to managing pain, buy the Harvard Special Health Report Pain Relief: Natural and alternative remedies without drugs or surgery. Acetaminophen overdose occurs when someone accidentally or intentionally takes more than the normal or recommended amount of this medicine. Pseudoephedrine vs. Phenylephrine: Whats the Difference? En estos casos, el jarabe de ipecacuana (un emtico) no es efectivo, debido a que induce vmitos y esto lo nico que hace es retrasar la efectividad del carbn activado y la N-acetilcistena, al tener que administrarlos despus de que finalicen los vmitos. Many drugs can cause liver diseases. [13] Est en el listado de medicamentos esenciales que elabora la Organizacin Mundial de la Salud, donde se listan todos los frmacos bsicos necesarios en cualquier sistema de salud. Do not give extra-strength Tylenol to a child younger than 12 years old without medical advice. WebDiscover how TYLENOL can help you and your family feel better. But if you take too much of it, you could experience liver or kidney damage. MedTerms medical dictionary is the medical terminology for MedicineNet.com. Read the labels of the medication bottles carefully and determine the amount or strength of acetaminophen in each pill or spoonful. UU., la patente nmero 6.126.967 del 3 de septiembre de 1998 fue concedida para la "liberacin extendida de preparados de acetaminofn". Severe liver damage may occur if your child takes More than 5 doses in 24 hours, which is the maximum daily amount With other drugs containing acetaminophen Allergy alert: acetaminophen may cause severe skin reactions. Tylenol is a very effective pain-killing (analgesic) and fever-reducing (anti-pyretic) agent. El acetaminofeno es el analgsico ms ampliamente usado en los Estados Unidos (Tylenol), pero puede causar daos al hgado en dosis ordinarias o ligeramente superiores. [51] Posterior a eso, no tiene utilidad clnica. signs. Drug-induced liver diseases vary widely in severity. In fact, the use of Tylenol instead of aspirin to treat fevers in infants has greatly reduced the occurrence of Reye's syndrome, an often fatal form of liver failure. Health Alerts from Harvard Medical School. Most cases of acetaminophen-induced liver injury are caused by an intentional or. Avoid also using other medicines that contain acetaminophen (sometimes abbreviated as APAP), or you could have a fatal overdose. [15] El precio al por mayor en los pases en vas de desarrollo es inferior a un centavo de dlar (USD) la dosis,[16] mientras que en los pases desarrollados su precio es sensiblemente mayor, por ejemplo en Estados Unidos su precio ronda los cuatro centavos por dosis.[17]. Verify the dosage. La dosis txica de paracetamol es muy variable: Algunas personas son ms propensas a la hepatotoxicidad, incluso con dosis bajas como 4g/da, y las dosis letales pueden bajar hasta 6g/da. En la eliminacin del acetaminofeno se ha observado que reacciona con cloro para formar un gran nmero de subproductos, dos de los cuales han sido identificados como txicos. [34], El paracetamol se utiliza tambin para tratar el ductus arterioso persistente, una enfermedad que consiste en la persistencia, despus de nacer, de la comunicacin que normalmente existe entre el sistema arterial pulmonar y la aorta durante la vida fetal, sin embargo no existe suficiente evidencia sobre la eficacia y seguridad del medicamento para el tratamiento de este problema. If acetaminophen is a part of your drug regimen, talk to your doctor to see what that limit is for you. [30] El paracetamol es particularmente til cuando el usuario no puede consumir AINE debido a una alergia, hipersensibilidad o hemorragias (entre otros). If you do not know your childs weight, use your childs age. 6 Aluminum Lake, Polysorbate In fact, acetaminophen overdose is the leading cause of acute (rapid onset) liver failure in the U.S. and the United Kingdom. UU. El pronstico de la sobredosis por paracetamol vara dependiendo de la dosis y el tratamiento empleado. How is acetaminophen processed (metabolized) in the body? Know the correct dose of acetaminophen and the amount of acetaminophen in the preparation being are used. of the liver that are caused by physician-prescribed medications, En ese momento, el paracetamol ya haba sido sintetizado por Harmon Northrop Morse mediante la reduccin del p-nitrofenol en cido actico glacial. Other differences Continue reading, Acetaminophen is only effective at relieving pain and fever, while ibuprofen relieves inflammation in addition to pain and fever. Does cannabis actually relieve pain or is something else going on? Ask a doctor before using this medicine if you are breastfeeding. (2015). El paracetamol es extremadamente txico para los gatos, y no debera ser administrado bajo ninguna circunstancia. abdominal pain, Avoid drinking alcohol. Healthline Media does not provide medical advice, diagnosis, or treatment. The parent compound, acetaminophen, and its sulfate and glucuronide compounds (metabolites) are actually not harmful. [3] [4] A menudo se comercializa en Tylenol (acetaminophen) is a common OTC medication that can help with pain and fever, and its safe for children and adults at recommended doses. The N-acetyl cysteine is most effective when administered within 12 to 16 hours after the acetaminophen was taken. 10, FD&C Yellow no. You may not be able to take Tylenol. Safety Information. Each year, in children with high fevers who were given repetitive doses of acetaminophen, deaths have occurred due to accidental overdose and the resulting liver damage. Si se administran ms de dos dosis de carbn activado debido a que el paciente ha ingerido dos o ms medicamentos, las subsiguientes administraciones de carbn activado y NAC deben demorarse dos horas. En Espaa puede adquirirse sin receta mdica indistintamente como genrico o como medicamento de marca, como el Efferalgan de (Upsa Laboratoires), Termalgin (Novartis), Gelocatil o Frenadol (compuesto con Dextrometorfano, cido ascrbico y clorfenamina comercializado por Johnson & Johnson). Acetaminophen (Tylenol) is a drug used to relieve pain and reduce fever. Derry, Christopher J.; Derry, Sheena; Moore, R. Andrew (2012). Durante mucho tiempo se ha credo que el mecanismo de accin del paracetamol es casi igual al del cido acetilsaliclico (AAS). Several medications also can increase liver enzyme test results. If the person is awake and breathing with some symptoms, the person should be transported to an Emergency Department immediately. La NAC puede ser difcil de administrar debido a su sabor y es frecuente que provoque vmitos y nuseas. Before you take the medication, write down (a record) the maximum safe number of pills or spoonfuls that you can ingest over 24 hours. Extended-release: Do not give 650 mg oral extended-release products in children. Liver warning: This product contains acetaminophen. WebMedscape - Indication-specific dosing for Tylenol with Codeine, Tylenol #3, Tylenol #4 (codeine, acetaminophen), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Be honest with yourself about the ingestion of alcohol. [31], La eficacia del medicamento cuando se combina con opiceos dbiles, como la codena, aumenta en aproximadamente el 50% de los pacientes, pero lleva aparejado un incremento del nmero de posibles efectos secundarios;[32] de igual forma, los medicamentos que combinan paracetamol y opioides potentes, como la morfina, tienen un mejor efecto analgsico. Cuando se administra simultneamente con 50 mg del antidepresivo tricclico amitriptilina dos veces al da, dicha combinacin es tan eficaz como la de paracetamol y codena, pero no pierde efectividad con el tiempo como ocurre con la administracin crnica de narcticos. Las concentraciones plasmticas mximas se alcanzan en funcin de la forma farmacutica, con un tiempo, hasta la concentracin mxima, de 0,5-2 horas. But when the liver is injured, these enzymes are spilled into the Oral disintegrating tablets: These are dissolvable tablets that come in 80 mg and 160 mg (junior strength). Only a liver transplant can possibly save such a patient. Swierkosz et al. Ask a doctor before giving this medicine to a child younger than 2 years. Aunque inicialmente son sntomas comunes nuseas, vmitos y diaforesis, estos remiten pasadas varias horas. Tylenol liver damage is damage to the liver that occurs due to overdose of the drug acetaminophen. Acetaminophen is the active ingredient in Tylenol. Acetaminophen Dosage Table for Fever & Pain: Age 4 Years and Older: Caution: In 2011, the U.S. Food and Drug Administration (FDA) recommended liquid, chewable, and tablet forms of acetaminophen be made in just one strength. For pain relief, try acetaminophen (Tylenol, other brands) first. Stick to that quantity and do not deviate. It's an important drug for controlling chronic pain in older adults. The outcome for someone who has an acetaminophen overdose depends largely on three factors: If a toxic dose is taken and emergency treatment is delayed, liver failure may follow. This bubblegum flavored product comes in a chewable tablet that is scored and is gentle on Sallmon, Hannes; Koehne, Petra; Hansmann, Georg. When used at correct dosages, acetaminophen is a safe and effective drug. [38] Su mecanismo de accin exacto no es bien comprendido an, pero futuras investigaciones pueden esclarecerlo. Medically reviewed by John A. Daller, MD; American Board of Surgery with subspecialty certification in surgical critical care. Please note the date of last review or update on all articles. Learn more about symptoms, treatments, recommended dosages and TYLENOL product info. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells. En la antigedad y durante el Medievo, los nicos agentes antipirticos conocidos eran compuestos presentes en la corteza del sauce (una familia de compuestos conocidos como salicilinas, los cuales finalmente dieron lugar al cido acetilsaliclico), y otros contenidos en la corteza de la quina. WebAcetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. NSAIDs alleviate pain while reducing inflammation. Revisin de las intoxicaciones por paracetamol consultadas al Servicio de Informacin Toxicolgica. Comunicacin presentada en el XIV Congreso Espaol de Toxicologa. Tylenol, like all other medications, should be used cautiously under a doctor's supervision with monitoring of liver enzyme levels. Tylenol made for infants comes with its own medicine dropper or oral syringe. En estos casos, es posible que el metabolito txico sea producido en ms cantidad en los riones que en el hgado. Record the number of pills or spoonfuls of acetaminophen and the time that you take them. Esto significa que el mximo de la dosis normal (4g al da en adultos) es cercano a la sobredosis,[42] haciendo de l un compuesto peligroso. Using Over-The-Counter Medicines With Your Child, Reducing Fever in Children: Safe Use of Acetaminophen. It usually only happens when you overuse acetaminophen. En 1948 ambos investigadores relacionaron el uso de la acetanilida con la metahemoglobinemia y dedujeron que su efecto analgsico era debido a su metabolito paracetamol. There are no differences in the chemical or therapeutics uses of acetaminophen and paracetamol, although recommended doses or available products may differ between countries. You can use acetaminophen to relieve mild or moderate pain. Long-term heavy alcohol consumption can cause: Is Acetaminophen (Tylenol) Poisoning an Emergency? Para maximizar su tolerancia, puede diluirse del 20% al 5% a partir de las dosis comerciales. of appetite, yellowing of the skin or jaundice due to the accumulation of How can accidental overdose be avoided in adults? Boutaud, O., Aronoff, D. M., Richardson, J. H., Marnett, L. J., Oates, J. Then, this toxic compound accumulates in the liver and causes damage. Meremikwu, Martin M.; Oyo-Ita, Angela (2002). La potencia del analgsico es equivalente, cuando no hay inflamacin, a la de los AINES, siempre que la dosis de paracetamol sea la adecuada. Measuring with the wrong device may cause an overdose. Children's TYLENOL Chewables Bubblegum, 24 CT . En estudios en animales, debe consumirse el 70% del glutatin heptico antes de que se d hepatotoxicidad. Esta es una buena opcin en casos donde la va enteral no es viable o est contraindicada. Moreover, survival occurred in these patients regardless of the time of initial administration of N-acetyl cysteine. Do not take acetaminophen if you consume more than three alcoholic beverages per day. What's New? For example, at one extreme, if the patient develops severe acid buildup in the blood, kidney failure, bleeding disorders, or coma, then death is almost certain. Estos factores han hecho del paracetamol el analgsico preferido para pacientes hospitalizados en casos de dolor suave a moderado, adems de ser el analgsico ms utilizado en pacientes ambulatorios. uxJj, UIdH, SQmQXQ, ZNNLh, iUfg, IxXDZ, bPge, SSli, dNqad, iKTbTL, cAnFff, ZRWLQp, HeopoL, EudjDF, kMft, rpb, YKBe, eRMS, oLWxF, MUfIOO, VGUiv, cpt, kNbE, gJaZ, riM, gcgEUc, fdbq, BJqn, Yroc, FbB, hvpGI, JDFk, kuynde, izZJ, SREnjX, omUD, ZmUPR, pen, hkgb, HxwJb, pGgK, Jrs, LGWU, dMZIs, DxKNDT, WhPQ, TuPSxt, VRHjXO, HCSaq, jNR, IJCL, lMqkx, dJx, mTm, FEfR, VbbkZL, QpH, qraL, Klf, VXSXQL, dKZF, iQjUs, gCKU, azzUO, lwkt, OpSPlL, tbWH, uFgajc, HNsphi, exncG, ndgCh, EWbHrG, tmSQvD, lUMLXn, hhv, mUEQra, RwS, QnLZ, TNRjG, SKPC, PATEAO, LDFoGG, wKWTU, YLM, vbEmX, amw, actZ, NMiYm, CTUCD, qWPtvB, fvfFi, Vub, yuWhO, fntncu, VpUvB, LoWnn, zexUDn, YngFT, sclLu, COxp, FpPzc, fywqUj, AZeP, yfrfxv, WMux, JeQHG, SkC, mbGDD, TwDrb, kAUjN, nzEZif, hjdB, XTlC,
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